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Materials Research Institute

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Prof Marina Resmini

Professor of Materials Chemistry

Department School of Biological and Chemical Sciences
 1.05, Joseph Priestley Building, Mile End
Telephone +44 (0)20 7882 3268
Email m.resmini@qmul.ac.uk
Homepage http://www.sbcs.qmul.ac.uk/staff/marinaresmini.html

Research Interests

The main research interests of our group are at the interface between chemistry and biology, in the broad area of biomimetic systems, in particular artificial receptors and catalysts.

Work has focused on the synthesis and characterisation of novel enzyme-like catalysts, first via the catalytic antibody approach and more recently with molecular imprinted polymers. Molecular imprinting is a synthetic approach for the generation of recognition sites in a macromolecular matrix using a molecular template and functional monomers in a casting procedure.

Personal website: resminilab.sbcs.qmul.ac.uk

Key Publications

Ton X-A, Bui BTS, Resmini M, Bonomi P, Dika I, Soppera O and Haupt K (2013). A Versatile Fiber-Optic Fluorescence Sensor Based on Molecularly Imprinted Microstructures Polymerized in Situ. Angewandte Chemie-International Edition  vol. 52, (32) 8317-8321. 10.1002/anie.201301045

Cakir P, Cutivet A, Resmini M, Bui BTS and Haupt K (2013). Protein-size molecularly imprinted polymer nanogels as synthetic antibodies, by localized polymerization with multi-initiators. Adv Mater  vol. 25, (7) 1048-1051. 10.1002/adma.201203400

Servant A, Haupt K and Resmini M (2011). Tuning molecular recognition in water-soluble nanogels with enzyme-like activity for the kemp elimination. Chemistry: a European Journal  vol. 17, (39) 11052-11059. 10.1002/chem.201002747

Carboni D, Flavin K, Servant A, Gouverneur V and Resmini M (2008). The first example of molecularly imprinted nanogels with aldolase type I activity. Chemistry: a European Journal  vol. 14, (23) 7059-7065. 10.1002/chem.200800675

2017

Pellizzoni E, Tommasini M, Marangon E, Rizzolio F, Saito G, Benedetti F, Toffoli G, Resmini M and Berti F (2017). Corrigendum to Fluorescent molecularly imprinted nanogels for the detection of anticancer drugs in human plasma [Biosens. Bioelectron. 86 (2016) 913-919]. Biosens Bioelectron  vol. 94, 10.1016/j.bios.2017.03.042

Gutiérrez Ortiz AL, Berti F, Navarini L, Monteiro A, Resmini M and Forzato C (2017). Synthesis of p-coumaroylquinic acids and analysis of their interconversion. Tetrahedron Asymmetry  vol. 28, (3) 419-427. 10.1016/j.tetasy.2017.01.015

2016

Pellizzoni E, Tommasini M, Marangon E, Rizzolio F, Saito G, Benedetti F, Toffoli G, Resmini M and Berti F (2016). Fluorescent molecularly imprinted nanogels for the detection of anticancer drugs in human plasma. Elsevier  Biosensors and Bioelectronics  vol. 86, 913-919. 10.1016/j.bios.2016.07.087

Aksakal R, Resmini M and Becer CR (2016). SET-LRP of acrylates catalyzed by a 1 penny copper coin. Royal Society of Chemistry  Polymer Chemistry  vol. 7, (43) 6564-6569. 10.1039/c6py01295g

Papadimitriou SA, Robin MP, Ceric D, O'Reilly RK, Marino S and Resmini M (2016). Fluorescent polymeric nanovehicles for neural stem cell modulation. Nanoscale  vol. 8, (39) 17340-17349. 10.1039/c6nr06440j

Panagiotopoulou M, Salinas Y, Beyazit S, Kunath S, Duma L, Prost E, Mayes AG, Resmini M, Tse Sum Bui B and Haupt K (2016). Molecularly Imprinted Polymer Coated Quantum Dots for Multiplexed Cell Targeting and Imaging. Angew Chem Int Ed Engl  vol. 55, (29) 8244-8248. 10.1002/anie.201601122

Resmini M (2016). The 'Leaky Pipeline'. Chemistry  vol. 22, (11) 3533-3534. 10.1002/chem.201600292

Zieli¿ska K, Sun H, Campbell RA, Zarbakhsh A and Resmini M (2016). Smart nanogels at the air/water interface: structural studies by neutron reflectivity. Nanoscale  vol. 8, (9) 4951-4960. 10.1039/c5nr07538f

Jorge AR, Chernobryva M, Rigby SEJ, Watkinson M and Resmini M (2016). Incorporation of Cobalt-Cyclen Complexes into Templated Nanogels Results in Enhanced Activity. Chemistry  vol. 22, (11) 3764-3774. 10.1002/chem.201503946

Papadimitriou SA, Salinas Y and Resmini M (2016). Smart Polymeric Nanoparticles as Emerging Tools for Imaging--The Parallel Evolution of Materials. Chemistry  vol. 22, (11) 3612-3620. 10.1002/chem.201502610

Ray JV, Mirata F, Pérollier C, Arotcarena M, Bayoudh S and Resmini M (2016). Smart coumarin-tagged imprinted polymers for the rapid detection of tamoxifen. Anal Bioanal Chem  vol. 408, (7) 1855-1861. 10.1007/s00216-015-9296-8

Aksakal R, Resmini M and Becer CR (2016). Pentablock star shaped polymers in less than 90 minutes via aqueous SET-LRP. Polymer Chemistry  vol. 7, (1) 171-175. 10.1039/c5py01623a

2015

Mirata F and Resmini M (2015). Molecularly Imprinted Polymers for Catalysis and Synthesis. Adv Biochem Eng Biotechnol  vol. 150, 107-129. 10.1007/10_2015_319

2013

Servant A, Rogers S, Zarbakhsh A and Resmini M (2013). Polymeric organic nanogels: Structural studies and correlation between morphology and catalytic efficiency. New Journal of Chemistry  vol. 37, (12) 4103-4109. 10.1039/c3nj00462g

Ton X-A, Bui BTS, Resmini M, Bonomi P, Dika I, Soppera O and Haupt K (2013). A Versatile Fiber-Optic Fluorescence Sensor Based on Molecularly Imprinted Microstructures Polymerized in Situ. Angewandte Chemie-International Edition  vol. 52, (32) 8317-8321. 10.1002/anie.201301045

Cakir P, Cutivet A, Resmini M, Bui BTS and Haupt K (2013). Protein-size molecularly imprinted polymer nanogels as synthetic antibodies, by localized polymerization with multi-initiators. Adv Mater  vol. 25, (7) 1048-1051. 10.1002/adma.201203400

2012

Bonomi P, Servant A and Resmini M (2012). Modulation of imprinting efficiency in nanogels with catalytic activity in the Kemp elimination. J Mol Recognit  vol. 25, (6) 352-360. 10.1002/jmr.2180

Resmini M (2012). Molecularly imprinted polymers as biomimetic catalysts. Anal Bioanal Chem  vol. 402, (10) 3021-3026. 10.1007/s00216-011-5671-2

Resmini M, Flavin K and Carboni D (2012). Microgels and nanogels with catalytic activity. Top Curr Chem  vol. 325, 307-342. 10.1007/128_2010_93

2011

Hussain S, Khan A, Gul S, Resmini M, Verma CS, Thomas EW and Brocklehurst K (2011). Identification of interactions involved in the generation of nucleophilic reactivity and of catalytic competence in the catalytic site Cys/His ion pair of papain. Biochemistry  vol. 50, (49) 10732-10742. 10.1021/bi201207z

Servant A, Haupt K and Resmini M (2011). Tuning molecular recognition in water-soluble nanogels with enzyme-like activity for the kemp elimination. Chemistry: a European Journal  vol. 17, (39) 11052-11059. 10.1002/chem.201002747

2010

Flavin K and Resmini M (2010). Molecular Imprinting with Nanomaterials. Advanced Nanomaterials  10.1002/9783527628940.ch20

Flavin K and Resmini M (2010). ADVANCED NANOMATERIALS, 2 VOLUMES. Advanced Nanomaterials, 2 Volumes , Editors: GECKELER KE and NISHIDE H. Wiley Vch 

2009

Pasetto P, Flavin K and Resmini M (2009). Simple spectroscopic method for titration of binding sites in molecularly imprinted nanogels with hydrolase activity. Biosens Bioelectron  vol. 25, (3) 572-578. 10.1016/j.bios.2009.03.042

Servant AMLI and Resmini M (2009). COLL 487-Catalytic imprinted nanogels for Kemp elimination: Synthesis and characterization. Abstr Pap Am Chem S  vol. 238,

Jorge R, Watkinson M, Resmini M, Biffis A and Svoboda J (2009). CATL 63-Molecularly imprinted nanogels as phosphate hydrolysis promoters. Abstr Pap Am Chem S  vol. 238,

Flavin K and Resmini M (2009). Imprinted nanomaterials: a new class of synthetic receptors. Anal Bioanal Chem  vol. 393, (2) 437-444. 10.1007/s00216-008-2496-8

2008

Carboni D, Flavin K, Servant A, Gouverneur V and Resmini M (2008). The first example of molecularly imprinted nanogels with aldolase type I activity. Chemistry (Weinheim An Der Bergstrasse, Germany)  vol. 14, (23) 7059-7065.

Gul S, Hussain S, Thomas MP, Resmini M, Verma CS, Thomas EW and Brocklehurst K (2008). Generation of nucleophilic character in the Cys25/His159 ion pair of papain involves Trp177 but not Asp158. Biochemistry  vol. 47, (7) 2025-2035. 10.1021/bi702126p

Carboni D, Flavin K, Servant A, Gouverneur V and Resmini M (2008). The first example of molecularly imprinted nanogels with aldolase type I activity. Chemistry: a European Journal  vol. 14, (23) 7059-7065. 10.1002/chem.200800675

2007

Boucher G, Said B, Ostler EL, Resmini M, Brocklehurst K and Gallacher G (2007). Evidence that the mechanism of antibody-catalysed hydrolysis of arylcarbamates can be determined by the structure of the immunogen used to elicit the catalytic antibody. Biochem J  vol. 401, (3) 721-726. 10.1042/BJ20060551

2005

RESMINI M, Ostler EL, Brocklehurst K and Gallacher G (2005). Polyclonal catalytic antibodies. Catalytic Antibodies , Editors: Keinan E. Wiley-Vch  10.1002/3527603662.ch17

2004

Sonkaria S, Boucher G, Flórez-Olvarez J, Said B, Hussain S, Ostler EL, Gul S, Thomas EW, Resmini M, Gallacher G and Brocklehurst K (2004). Evidence for 'lock and key' character in an anti-phosphonate hydrolytic antibody catalytic site augmented by non-reaction centre recognition: variation in substrate selectivity between an anti-phosphonate antibody, an anti-phosphate antibody and two hydro. Biochem J  vol. 381, (Pt 1) 125-130. 10.1042/BJ20031966

Rodriguez AC, Ramos AP, Hawkes GE, Berti F and Resmini M (2004). Stereoselective synthesis of a novel pseudopeptide hapten for the generation of hydrolytic catalytic antibodies. Tetrahedron-Asymmetr  vol. 15, (12) 1847-1855. 10.1016/j.tetasy.2004.05.005

Maddock SC, Pasetto P and Resmini M (2004). Novel imprinted soluble microgels with hydrolytic catalytic activity. Chem Commun  (5) 536-537. 10.1039/b312631e

Reid JD, Hussain S, Bailey TSF, Sonkaria S, Sreedharan SK, Thomas EW, Resmini M and Brocklehurst K (2004). Isomerization of the uncomplexed actinidin molecule: kinetic accessibility of additional steps in enzyme catalysis provided by solvent perturbation. Biochem J  vol. 378, (Pt 2) 699-703. 10.1042/BJ20031318

Maggiotti V, Bahmanyar S, Reiter M, Resmini M, Houk KN and Gouverneur V (2004). Unusual reversal of regioselectivity in antibody-mediated aldol additions with unsymmetrical methyl ketones. Tetrahedron  vol. 60, (3) 619-632. 10.1016/j.tet.2003.10.115

2003

Gul S, Sonkaria S, Pinitglang S, Florez-Alvarez J, Hussain S, Thomas EW, Ostler EL, Gallacher G, Resmini M and Brocklehurst K (2003). Improvement in hydrolytic antibody activity by change in haptenic structure from phosphate to phosphonate with retention of a common leaving-group determinant: evidence for the 'flexibility' hypothesis. Biochem J  vol. 376, (Pt 3) 813-821. 10.1042/BJ20030716

Hussain S, Pinitglang S, Bailey TSF, Reid JD, Noble MA, Resmini M, Thomas EW, Greaves RB, Verma CS and Brocklehurst K (2003). Variation in the pH-dependent pre-steady-state and steady-state kinetic characteristics of cysteine-proteinase mechanism: evidence for electrostatic modulation of catalytic-site function by the neighbouring carboxylate anion. Biochem J  vol. 372, (Pt 3) 735-746. 10.1042/BJ20030177

2002

Ostler EL, Dean CJ, Barber N, Valeri M, James S, Resmini M, Boucher G, Romanov N, Brocklehurst K and Gallacher G (2002). A rat monoclonal antibody that catalyses the hydrolysis of a nitrophenyl-beta-lactam. Biochem Biophys Res Commun  vol. 299, (2) 273-276. 10.1016/S0006-291X(02)02604-9

Ostler EL, Resmini M, Brocklehurst K and Gallacher G (2002). Polyclonal catalytic antibodies. J Immunol Methods  vol. 269, (1-2) 111-124. 10.1016/S0022-1759(02)00228-4

Maggiotti V, Bahmanyar S, Houk KN, Gouverneur V and Resmini M (2002). Theoretical studies on the antibody-catalyzed aldol reaction involving unsymmetrical enamine intermediates. Abstr Pap Am Chem S  vol. 223, B188-B188.

Maggiotti V, Gouverneur V and Resmini M (2002). Unprecedented regiocontrol using an aldolase I antibody. Abstr Pap Am Chem S  vol. 223, B215-B215.

Maggiotti V, Resmini M and Gouverneur V (2002). Unprecedented regiocontrol using an aldolase I antibody. Angew Chem Int Ed Engl  vol. 41, (6) 1012-1014. 10.1002/1521-3773

Ostler EL, Resmini M, Boucher G, Romanov N, Brocklehurst K and Gallacher G (2002). Polyclonal antibody-catalysed hydrolysis of a beta-lactam. Chem Commun (Camb)  (3) 226-227. 10.1039/b110135h

Florez-Alvarez J, Brocklehurst K, Gallacher G and RESMINI M (2002). Synthesis of an aminoalcohol hapten for the generation of catalytic antibodies. Tet. Lett.  vol. 43, (1) 171-174. 10.1016/S0040-4039(01)02101-3

2001

Brocklehurst K, Resmini M and Topham CM (2001). Kinetic and titration methods for determination of active site contents of enzyme and catalytic antibody preparations. Methods  vol. 24, (2) 153-167. 10.1006/meth.2001.1176

Krell T, Maclean J, Boam DJ, Cooper A, Resmini M, Brocklehurst K, Kelly SM, Price NC, Lapthorn AJ and Coggins JR (2001). Biochemical and X-ray crystallographic studies on shikimate kinase: the important structural role of the P-loop lysine. Protein Sci  vol. 10, (6) 1137-1149. 10.1110/ps.52501

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