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Materials Research Institute

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Prof Mike Watkinson

Professor in Synthetic Chemistry

Department School of Biological and Chemical Sciences
 G.02, Joseph Priestley Building, Mile End
Telephone +44 (0)20 7882 3263
Email m.watkinson@qmul.ac.uk
Homepage http://www.sbcs.qmul.ac.uk/staff/mikewatkinson.html

Research Keywords

Sensors, Catalysis, Supramolecular Chemistry, Coordination Chemistry

Research Interests

Current research interests focus on the custom design and synthesis of novel functional ligand systems, especially those derived from azamacrocyclic ligands, and their metal complexes, especially manganese, for application in a range of projects including the development of novel bleaching catalysts for application in domestic laundry, asymmetric epoxidation catalysts, and a number of biomimetic complexes.

More recently we have become engaged in the development of a number of novel sensor agents, including agents for the sensing of the binding of biological analytes , Zn sensors  and novel hydrogels for the detection of periodontal disease (with Steffi Krause, School of Engineering and Materials Science).

Personal website: www.chem.qmul.ac.uk/staff/watkinson

Key Publications

Jobe K, Brennan CH, Motevalli M, Goldup SM and Watkinson M (2011). Modular 'click' sensors for zinc and their application in vivo. Chem Commun (Camb)  vol. 47, (21) 6036-6038. 10.1039/c1cc11213a

Tamanini E, Flavin K, Motevalli M, Piperno S, Gheber LA, Todd MH and Watkinson M (2010). Cyclam-based clickates: homogeneous and heterogeneous fluorescent sensors for Zn(II). Inorg Chem  vol. 49, (8) 3789-3800. 10.1021/ic901939x

Tamanini E, Katewa A, Sedger LM, Todd MH and Watkinson M (2009). A synthetically simple, click-generated cyclam-based zinc(II) sensor. Inorg Chem  vol. 48, (1) 319-324. 10.1021/ic8017634

Tamanini E, Rigby SE, Motevalli M, Todd MH and Watkinson M (2009). Responsive metal complexes: a click-based allosteric scorpionate complex permits the detection of a biological recognition event by EPR/ENDOR spectroscopy. Chemistry- a European Journal  vol. 15, (15) 3720-3728. 10.1002/chem.200802425

2017

Wu F, Zhang D, Wang J, Watkinson M and KRAUSE SK (2017). Copper contamination of self-assembled organic monolayer modified silicon surfaces following a ?click? reaction characterized with LAPS and SPIM. American Chemical Society  Langmuir  10.1021/acs.langmuir.6b03831

2016

WATKINSON M, Motevalli M, Evans V and Duncanson P (2016). An investigation into the synthesis of azido-functionalised coumarins for application in 1,3-dipolar ?click? cycloaddition reactions. Elsevier  Dyes and Pigments  vol. 135, (Special issue) 36-40. 10.1016/j.dyepig.2016.06.028

Zhang DW, Wu F, Wang J, Watkinson M and KRAUSE SK (2016). Image detection of yeast Saccharomyces cerevisiae by light-addressable potentiometric sensors (LAPS). Electrochemistry Communications  vol. 72, 41-45. 10.1016/j.elecom.2016.08.017

Johnston NR, Mitchell RK, Haythorne E, Pessoa MP, Semplici F, Ferrer J, Piemonti L, Marchetti P, Bugliani M, Bosco D, Berishvili E, Duncanson P, Watkinson M, Broichhagen J, Trauner D, Rutter GA and Hodson DJ (2016). Beta Cell Hubs Dictate Pancreatic Islet Responses to?Glucose. Elsevier (Cell Press)  Cell Metabolism  vol. 24, (3) 389-401. 10.1016/j.cmet.2016.06.020

Wang J, Campos I, Wu F, Zhu J, Sukhorukov GB, Palma M, Watkinson M and Krause S (2016). The effect of gold nanoparticles on the impedance of microcapsules visualized by scanning photo-induced impedance microscopy. Electrochimica Acta  vol. 208, 39-46. 10.1016/j.electacta.2016.05.017

Jorge AR, Chernobryva M, Rigby SEJ, Watkinson M and Resmini M (2016). Incorporation of Cobalt-Cyclen Complexes into Templated Nanogels Results in Enhanced Activity. Chemistry  vol. 22, (11) 3764-3774. 10.1002/chem.201503946

2015

Wang J, Wu F, Watkinson M, Zhu J and Krause S (2015). click Patterning of Self-Assembled Monolayers on Hydrogen-Terminated Silicon Surfaces and Their Characterization Using Light-Addressable Potentiometric Sensors. Langmuir  vol. 31, (35) 9646-9654. 10.1021/acs.langmuir.5b02069

Wang J, Zhou Y, Watkinson M, Gautrot J and Krause S (2015). High-sensitivity light-addressable potentiometric sensors using silicon on sapphire functionalized with self-assembled organic monolayers. Elsevier  Sensors and Actuators B: Chemical  vol. 209, 230-236. 10.1016/j.snb.2014.11.071

Biela A, Watkinson M, Meier UC, Baker D, Giovannoni G, Becer CR and Krause S (2015). Disposable MMP-9 sensor based on the degradation of peptide cross-linked hydrogel films using electrochemical impedance spectroscopy. Biosensors and Bioelectronics  vol. 68, 660-667. 10.1016/j.bios.2015.01.060

2014

Pancholi J, Hodson DJ, Jobe K, Rutter GA, Goldup SM and Watkinson M (2014). Biologically targeted probes for Zn2+: a diversity oriented modular click-SNAr-click approach. Chemical Science  vol. 5, (9) 3528-3535. 10.1039/c4sc01249f

Ilyashenko G, De Faveri G, Follier T, Al-Safadi R, Motevalli M and Watkinson M (2014). Catalytic and mechanistic studies into the epoxidation of styrenes using manganese complexes of structurally similar polyamine ligands. Org Biomol Chem  vol. 12, (7) 1124-1134. 10.1039/c3ob42274g

2013

Ilyashenko G, De Faveri G, Masoudi S, Al-Safadi R and Watkinson M (2013). Initial rate kinetic studies show an unexpected influence of para-substituents on the catalytic behaviour of manganese complexes of TMTACN in the epoxidation of styrenes with H2O2. Org Biomol Chem  vol. 11, (12) 1942-1951. 10.1039/c3ob27217f

DONNAN RS, Pickersgill R, Krauss N, Yang B and Sushko O (2013). Lagrangian dynamics analysis of sub-THz skeletal absorption spectra of amino acids acquired by vector network analysis. Elsevier  Chemical Physics Letters  vol. 558, 104-108. 10.1016/j.cplett.2012.12.044

Ilyashenko G, Al-Safadi R, Donnan R, Dubrovka R, Pancholi J, Watkinson M and Whiting A (2013). A synthesis of a 1,1 '-desymmetrised ferrocene backbone and its facile one-pot double-click functionalisation. Rsc Advances  vol. 3, (38) 17081-17087. 10.1039/c3ra43054e

McIntosh A, Yang B, Goldup S and Wilkinson M (2013). Crystallization of Amorphous Lactose at High Humidity Studied by Terahertz Time Domain Spectroscopy. Elsevier/Science Direct  Chemical Physics Letters  vol. 558, 104-108. 10.1016/j.cplett.2012.12.044,

2012

McIntosh AI, Yang B, Goldup SM, Watkinson M and Donnan RS (2012). Terahertz spectroscopy: a powerful new tool for the chemical sciences? Chem Soc Rev  vol. 41, (6) 2072-2082. 10.1039/c1cs15277g

2011

Jobe K, Brennan CH, Motevalli M, Goldup SM and Watkinson M (2011). Modular 'click' sensors for zinc and their application in vivo. Chem Commun (Camb)  vol. 47, (21) 6036-6038. 10.1039/c1cc11213a

Lahlali H, Jobe K, Watkinson M and Goldup SM (2011). Macrocycle size matters: small functionalized rotaxanes in excellent yield using the CuAAC active template approach. Angew Chem Int Ed Engl  vol. 50, (18) 4151-4155. 10.1002/anie.201100415

De Faveri G, Ilyashenko G and Watkinson M (2011). Recent advances in catalytic asymmetric epoxidation using the environmentally benign oxidant hydrogen peroxide and its derivatives. Chem Soc Rev  vol. 40, (3) 1722-1760. 10.1039/c0cs00077a

Lau YH, Rutledge PJ, Watkinson M and Todd MH (2011). Chemical sensors that incorporate click-derived triazoles. Chem Soc Rev  vol. 40, (5) 2848-2866. 10.1039/c0cs00143k

Zheng XW, Cook JP, Watkinson M, Yang SF, Douglas I, Rawlinson A and Krause S (2011). Generic protease detection technology for monitoring periodontal disease. Faraday Discuss  vol. 149, 37-47. 10.1039/c005364c

2010

Tamanini E, Flavin K, Motevalli M, Piperno S, Gheber LA, Todd MH and Watkinson M (2010). Cyclam-based clickates: homogeneous and heterogeneous fluorescent sensors for Zn(II). Inorg Chem  vol. 49, (8) 3789-3800. 10.1021/ic901939x

Martínez D, Motevalli M and Watkinson M (2010). Is there really a diagnostically useful relationship between the carbon-oxygen stretching frequencies in metal carboxylate complexes and their coordination mode? Dalton Trans  (2) 446-455. 10.1039/b913865j

WATKINSON M, Andreou A, Eames J, Motevalli M and Prior T (2010). Desymmetrisation of (4R,5S)-4,5-diphenylimidazolidine-2-thione using pentafluorophenyl active esters. Elsevier  Tetrahedron Letters  vol. 51, 1423-1425. 10.1016/j.tetlet.2010.01.019

Sheriff TS, Watkinson M, Motevalli M and Lesin JF (2010). Unexpected formation of a novel pyridinium-containing catecholate ligand and its manganese(III) complex. Dalton Trans  (1) 53-55. 10.1039/b915747f

2009

Jorge R, Watkinson M, Resmini M, Biffis A and Svoboda J (2009). CATL 63-Molecularly imprinted nanogels as phosphate hydrolysis promoters. Abstr Pap Am Chem S  vol. 238,

Stair JL, Watkinson M and Krause S (2009). Sensor materials for the detection of proteases. Biosens Bioelectron  vol. 24, (7) 2113-2118. 10.1016/j.bios.2008.11.002

Tamanini E, Katewa A, Sedger LM, Todd MH and Watkinson M (2009). A synthetically simple, click-generated cyclam-based zinc(II) sensor. Inorg Chem  vol. 48, (1) 319-324. 10.1021/ic8017634

Tamanini E, Rigby SE, Motevalli M, Todd MH and Watkinson M (2009). Responsive metal complexes: a click-based allosteric scorpionate complex permits the detection of a biological recognition event by EPR/ENDOR spectroscopy. Chemistry- a European Journal  vol. 15, (15) 3720-3728. 10.1002/chem.200802425

2008

Ilyashenko G, Sale D, Motevalli M and Watkinson M (2008). A preliminary investigation into a rationally designed catalytic system for the epoxidation of alkenes based on a bipyridyl core. J Mol Catal a-Chem  vol. 296, (1-2) 1-8. 10.1016/j.molcata.2008.07.011

Ramana AV, Watkinson M and Todd MH (2008). Synthesis and DNA binding ability of cyclam-amino acid conjugates. Bioorg Med Chem Lett  vol. 18, (9) 3007-3010. 10.1016/j.bmcl.2008.03.045

2007

Krivickas SJ, Tamanini E, Todd MH and Watkinson M (2007). Effective methods for the biotinylation of azamacrocycles. J Org Chem  vol. 72, (22) 8280-8289. 10.1021/jo071175v

Shastri K, Cheng EWC, Motevalli M, Schofield J, Wilkinson JS and Watkinson M (2007). Investigations into the efficacy of methyhlphosphonic acid functionalised 1,4,7-triazacyclononane ligands in bleaching catalysis. Green Chem  vol. 9, (9) 996-1007. 10.1039/b609710c

2006

Tamanini E, Watkinson M and Todd MH (2006). Improved synthesis of the valuable peptidomimetic intermediate 3-azido-4-hydroxy cyclopentanoic acid. Tetrahedron-Asymmetr  vol. 17, (15) 2235-2239. 10.1016/j.tetasy.2006.07.001

Ilyashenko G, Motevalli M and Watkinson M (2006). An alternative model for the asymmetric addition of cyanide to aldehydes catalysed by titanium-salen complexes based on a structurally related iron-salen complex. Tetrahedron-Asymmetr  vol. 17, (11) 1625-1628. 10.1016/j.tetasy.2006.06.018

Ilyashenko G, Choudhury R, Motevalli M and Watkinson M (2006). Concentration-dependent chemo- and regioselective metalation of 6,6 '-dibromo-2,2 '-bipyridine. Synlett  (11) 1759-1761. 10.1055/s-2006-944192

Sibbons KF, Shastri K and Watkinson M (2006). The application of manganese complexes of ligands derived from 1,4,7-triazacyclononane in oxidative catalysis. Dalton Trans  (5) 645-661. 10.1039/b511331h

2005

Scheuermann JEW, Bento ES, Hawkes GE and Watkinson M (2005). NMR investigation into the dynamic behaviour of a novel C2-symmetric macrocyclic ligand. Magn Reson Chem  vol. 43, (4) 321-325. 10.1002/mrc.1539

Coumbarides GS, Eames J, Scheuermann JEW, Sibbons KF, Suggate MJ and WATKINSON M (2005). Enantioselective protonation of a lithium enolate derived from 2-methyl-1-tetralone using chiral sulfonamides. Bull. Chem. Soc. Jpn.  vol. 78, (5) 906-909. 10.1246/bcsj.78.906

2004

Scheuermann JEW, Sibbons KF, Benoit DM, Motevalli M and Watkinson M (2004). The synthesis of unsymmetrically N-substituted chiral 1,4,7-triazacyclononanes. Org Biomol Chem  vol. 2, (18) 2664-2670. 10.1039/B409259G

Sibbons KF, Al-Hashimi M, Motevalli M, Wolowska J and Watkinson M (2004). Rare and unexpected coordination to copper(II) by a tertiary amide in a macrocyclic ligand. Dalton T  (20) 3163-3165. 10.1039/b410525g

2003

Pulacchini S, Nasser R, Sibbons KF, Motevalli M, Hawkes GE, Kroemer RT, Bento ES and Watkinson M (2003). Structure, modelling and dynamic behaviour of aza- and azaoxamacrocyclic ligands derived from (R,R)-1,2-diaminocyclohexane. Org Biomol Chem  vol. 1, (22) 4058-4063. 10.1039/b306963j

Lamond S, WATKINSON M, Rutherford T, Laing K, Whiting A, Smallwood A, Nargund G, Campbell S and Banerjee S (2003). Gene-specific chromatin damage in human spermatozoa can be blocked by antioxidants that target mitochondria. Reproductive Biomedicine  vol. 7, (4) 407-418. 10.1016/S1472-6483(10)61884-6

2002

Pulacchini S, Abrahams I, Eames J and Watkinson M (2002). Conformational chiral recognition in a simple urea. Supramol Chem  vol. 14, (4) 353-357. 10.1080/10610270290029407

Martínez D, Motevalli M and Watkinson M (2002). Aquachloro[N,N'-ethylenebis(salicylideneiminato)]manganese(III). Acta Crystallogr C  vol. 58, (Pt 4) M258-M260. 10.1107/S0108270102003529

Scheuermann JEW, Ilyashenko G, Griffiths DV and Watkinson M (2002). Solvent-mediated selective single and double ring-opening of N-tosyl-activated aziridines using benzylamine. Tetrahedron-Asymmetr  vol. 13, (3) 269-272. 10.1016/S0957-4166(02)00102-7

Coveney PV, Griffin JLW, Watkinson M, Whiting A and Boek ES (2002). Novel non-exfoliated clay-nanocomposite materials by in situ co-polymerisation of intercalated monomers: A combinatorial discovery approach. Mol Simulat  vol. 28, (3) 295-316. 10.1080/08927020290014394

Scheuermann JEW, Ronketti F, Motevalli M, Griffiths DV and Watkinson M (2002). The synthesis of C-2-symmetric 1,4,7-triazacyclononane ligands derived from chiral aziridines. New J Chem  vol. 26, (8) 1054-1059. 10.1039/b204818c

Eames J and WATKINSON M (2002). Metalloenzymes and electrophilic catalysis. Encyclopaedia of Life Sciences , Editors: Robertson S. Nature Publishing Group 

EAMES J and Watkinson M (2002). Polymeric Scavengers for Efficient Organic Synthesis. Organic Synthesis Highlights V , Editors: Schmaltz H. Vch-Wiley  10.1002/9783527620784.ch26d

2001

Pulacchini S, Shastri K, Dixon NC and Watkinson M (2001). A remarkably efficient and direct route for the synthesis of binucleating 1,4,7-triazacyclononane ligands. Synthesis-Stuttgart  (16) 2381-2383.

Pulacchini S and Watkinson M (2001). An efficient route to symmetrically and unsymmetrically substituted azamacrocyclic ligands. Eur J Org Chem  (22) 4233-4238.

Eames J and Watkinson M (2001). Catalytic Allylic Oxidation of Alkenes Using an Asymmetric Kharasch-Sosnovsky Reaction. Angew Chem Int Ed Engl  vol. 40, (19) 3567-3571. 10.1002/1521-3773(20011001)40:19<3567::AID-ANIE3567>3.0.CO;2-C

Cross W, Hawkes GE, Kroemer RT, Liedl KR, Loerting T, Nasser R, Pritchard RG, Steele M, Watkinson M and Whiting A (2001). The structure, modelling and dynamics of hindered 5,6-diarylacenaphthenes. J Chem Soc Perk T 2  (4) 459-467. 10.1039/b008788m

Eames J and Watkinson M (2001). Polymeric scavenger reagents in organic synthesis. Eur J Org Chem  (7) 1213-1224.

Eames J and WATKINSON M (2001). Oxidation not involving epoxidation. Rodd\'s Chemistry of Carbon Compounds; a Modern Comprehensive Treatise , Editors: Sainsbury M. Elsevier Publishing  10.1016/B978-044453347-0.50418-3

Steele M, Watkinson M and Whiting A (2001). Attempts to find a solution to the problem of atropisomer interconversion in 1,8-diarylnaphthalenes and 5,6-diarylacenaphthenes. J Chem Soc Perk T 1  (6) 588-598. 10.1039/b008319o

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